Application

Phenylsulfanyltetrafluoropropionic acid Cs salt is as a less hygroscopic, crystalline source of phenylsulfanyltetrafluoropropionic acid. A phenylsulfanyltetrafluoroethyl moiety incorporated in the substrate can be treated with tributyltin hydride and generate the corresponding fluoroalkyl radical. If the substrate lacks any olefins, it can be reduced to tetrafluoroethyl group whereas if the substrate contains an olefin in the correct spatial orientation, it can lead to an intramolecular cyclization affording tetrafluorinated cyclic structures.

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Other Notes

Technology Spotlight: Fluoroalkylation: Expansion of Togni Reagents